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November 1911


Arch Intern Med (Chic). 1911;VIII(5):581-590. doi:10.1001/archinte.1911.00060110027003

Since the observations made by one of us1 of ameboid movements in a megaloblast, the opportunity has presented itself to study the fresh blood of five severe anemias.

In three of the bloods examined by us, ameboid motion was striking not only in many of the megaloblasts but also in the macrocytes. The absence of ameboid activity in the two remaining cases was probably attributable to the almost complete lack of unusually large cells in the blood. (For the blood findings, see the accompanying table.)

Two of the bloods (Cases 1 and 2) were demonstrated to the class and the changes described below were observed by practically all of the ninety-odd students. In addition, we made prolonged observations on each of the bloods. Our specimens were sealed at once with petrolatum to prevent drying and to avoid currents in the plasma as far as possible.

In Case 1, preparations of