An attempt has been made in the present research to determine approximately the length of time during which the action of several of the digitalins persists after the introduction of suitable doses directly into the circulation, with the hope of throwing some light on their so-called cumulative action.
One finds many references in the literature to this so-called cumulative action of the digitalins, but there have been few investigations of the phenomena other than clinical.
The term cumulation is used somewhat loosely, but it is generally understood to mean the action which is manifested rather suddenly after the continued use of doses which singly do not cause perceptible effects. Van der Heide1 states that Mégevaud was the first to study this subject by means of animal experimentation in 1879, but the research was incomplete, so far as cumulation was concerned, since that investigator was interested mainly in the histologic
HATCHER RA. THE PERSISTENCE OF ACTION OF THE DIGITALINS. Arch Intern Med (Chic). 1912;X(3):268–296. doi:10.1001/archinte.1912.00060210102009
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