The question as to how completely foreign proteins introduced parenterally can be utilized by the animal organism is one that has been under discussion and investigation for more than forty years. The earliest method of attack was that of injecting a protein, such as eggwhite or foreign blood-serum and testing the urine for coagulable protein, on the assumption that if the protein could not be utilized by the body it would be eliminated promptly in the urine in coagulable form. If, therefore, no coagulable protein was found after such injection the protein was supposed to have been utilized by the body. Stokvis,1 Ponfick,2 Ott3 and Lilienfeld4 have reported experiments of this type and have found that in the dog and the rabbit the injection of egg albumin is followed by albuminuria while injection of blood-serum is not. Other proteins of animal or vegetable origin
AUSTIN JH, EISENBREY AB. THE UTILIZATION OF PARENTERALLY INTRODUCED SERUM. Arch Intern Med (Chic). 1912;X(4):305–313. doi:10.1001/archinte.1912.00060220010002
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