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Article
December 1912

ERYTHREMIA, OR POLYCYTHEMIA WITH CHRONIC CYANOSIS AND SPLENOMEGALYREPORT OF TWO CASES WITH A SUMMARY OF 179 CASES REPORTED TO DATE

Arch Intern Med (Chic). 1912;X(6):597-667. doi:10.1001/archinte.1912.00060240079007
Abstract

Renewed interest has recently been shown in that primary form of polycythemia with chronic cyanosis and splenomegaly which was first brought to the attention of the profession in 1892 by H. Vaquez,1 and which has been well termed ``erythremia'' in contra-distinction to ``erythrocytosis'' or secondary polycythemia.

Erythremia was long considered a rare condition and as late as 1907 Mackey,2 in a most excellent thesis, was able to cite but about forty cases. During the past few years, however, the increasing number of patients reported from various sources indicates that the malady is not by any means as uncommon as was at first supposed. Indeed, Staehelin,3 in 1911, reported eleven cases of polycythemia which came under his observation in a single year, of which at least six appear to have been of the Vaquez type.

As the result of a recent careful search through medical literature, I

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