It is not the object of this article to enter into a discussion of the effect of strychnin or digitalis on the systems of the body as observed on the lower animals, or to go over the literature on the subject, but to report observations when these drugs were administered in therapeutic doses to normal young men.
Before entering on a report of the findings, I desire to call attention to the fact that text-books on pharmacology and highly scientific articles pertaining to this subject are based largely on experimental evidence furnished by the lower animals. This evidence has been and is of inestimable value in determining the presence and the location of an effect and establishes a valid reason for a continuance of the experimental work by making observations on the higher animal, man.
In a very few instances observations have been made on the normal man and
DAVID MARVIN. A PRELIMINARY REPORT ON THE EFFECT OF STRYCHNIN AND DIGITALIS ON MAN. Arch Intern Med (Chic). 1913;XI(4):418–424. doi:10.1001/archinte.1913.00060280057005