As a preface to the discussion of the urinary methylene-blue test for typhoid fever, it seems best to point out a few facts regarding the value of blood-cultures in the diagnosis of typhoid fever. By the use of the more modern methods for the isolation of the typhoid bacilli from the blood, the blood-culture has been so uniformly successful that it is now recognized as the diagnostic means, par excellence, especially for an early diagnosis. This procedure is, of course, to be recommended in all cases, but the average practitioner does not possess the necessary laboratory skill or apparatus for this test, the technic being rather difficult. It is for this reason that a number of tests which might be classed as secondary or corroborative are of much clinical value and significance, each one strengthening the physician's diagnostic armamentarium. The urinary methylene-blue test is placed in this class of
NEUMAN L, BEHREND EB. A MODIFICATION OF RUSSO'S URINARY TYPHOID FEVER TEST, WITH A REPORT OF ITS USE IN ONE THOUSAND CASES, AND A COMPLETE BIBLIOGRAPHY. Arch Intern Med (Chic). 1913;XI(4):456–467. doi:10.1001/archinte.1913.00060280095009
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