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May 1913


Author Affiliations


From the Department of Pathology, Harvard Medical School.

Arch Intern Med (Chic). 1913;XI(5):534-541. doi:10.1001/archinte.1913.00060290068009

REVIEW OF LITERATURE  An attempt has been made recently to isolate from the general group of lobular pneumonias a form in which the histological picture shows the presence of large multinucleated cells in the alveoli, not tuberculous in nature, a form of pneumonia which frequently follows acute infectious diseases of childhood, more particularly measles and pertussis.1 This giant-cell formation occurs especially in association with desquamative bronchopneumonia, a condition described by Buhl2 as early as 1856. In 18723 he described in addition certain multinucleated cells occurring in the same condition, but his description is not so complete as to make certain that he saw identically the type of multinucleated cell under discussion. In 1876, however, Friedländer4 gave a more complete description of a multinucleated cell appearing in the pneumonic processes which he produced experimentally by cutting the recurrent laryngeal nerves and these cells certainly are identical with

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