The exact etiology of hemoglobinuric fever is still undetermined. It has been considered the result of pernicious malarial infection in instances in which quinin will give relief;1 others consider it evidence of quinin intoxication;2 still others that we have here a duplex disease,3 quinin in some cases giving relief, in others hastening a fatal termination, a disease sui generis,4 where quinin is neither injurious nor beneficial. Some have advised the use of quinin only when the parasites can be demonstrated in the peripheral blood,5 still others believe that hemoglobinuric fever can be avoided if the quinin is given intramuscularly.6
Considering, then, the conflicting opinions as to the nature and treatment of hemoglobinuric fever, it is hoped that this article, based on 514 cases of blackwater fever, treated by American physicians in the hospital of the Madeira-Mamore Railway Company, Porto Velho, Brazil,
LOVELACE C. THE ETIOLOGY AND TREATMENT OF HEMOGLOBINURIC FEVER: A REPORT OF FIVE HUNDRED AND FOURTEEN CASES. Arch Intern Med (Chic). 1913;XI(6):674–684. doi:10.1001/archinte.1913.00060300111009
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