This study has been made at the suggestion of Dr. Henry A. Christian in an attempt to produce a chronic nephritis in animals in a manner comparable to that used by Opie1 in the production of an experimental cirrhosis of the liver. Opie found that repeated injections of chloroform, which causes a necrosis of the liver, and Bacillus coli communis, whose relation to the liver is quite intimate, produced a well-marked sclerosis of the liver. In the present experiments repeated injections of uranium nitrate and B. coli communis were made in rabbits to see if in similar way a sclerosis of the kidney would be produced. Uranium nitrate is known to produce an acute nephritis similar to that occurring in human beings in which there is very extensive necrosis of the tubular epithelium, and has been shown by Dickson,2 Smith3 and others, to produce a chronic nephritis
O'HARE JP. STUDY XVII: EXPERIMENTAL CHRONIC NEPHRITIS PRODUCED BY THE COMBINATION OF CHEMICAL (URANIUM NITRATE) AND BACTERIA: (B. COLI COMMUNIS). Arch Intern Med (Chic). 1913;XII(1):49–60. doi:10.1001/archinte.1913.00070010052004
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