Ever since the recognition of the many interesting phenomena revealed by the application of the method of vital staining to the erythrocyte, hematologists have been endeavoring to derive from these findings facts of practical importance. As each discovery was announced some significance was attached to it, and the hope was raised that thereby some light was to be shed on the etiology of blood-diseases or on the vexed question of destruction and regeneration of the blood. It is now almost twenty years since the erythrocyte began to be studied by this means, and during this time almost twenty varieties of intra-corpuscular phenomena have been demonstrated and a most voluminous literature has collected. The majority of these findings, however, have not as yet been shown to be of any significance, many have been explained as merely artefacts and only a few are now considered worthy of mention in the
PEPPER OHP, PEET MM. THE RESISTANCE OF RETICULATED ERYTHROCYTES. Arch Intern Med (Chic). 1913;XII(1):81–89. doi:10.1001/archinte.1913.00070010084007
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