The term polyglandular syndrome is used by most writers to express the disturbed function of two or more glands of internal secretion. Cushing1 has confined the term to cases in which it is impossible to tell which of the structures is primarily at fault. The combinations of the different glands is variable, as is the degree to which each is changed. From experimental data it is seen that the absence of the function of a normal gland (as for example, extirpation of that gland) leads to a definite symptom-complex in which some of the other glands participate. For instance, in the preadolescent eunuch, the impotency and the undeveloped secondary sexual characteristics are due to the immediate effects of the castration, while the growth of the long bones is thought to be due to a secondary hyperplasia of the anterior lobe of the hypophysis. Fischera2 and others, have definitely
BARTLETT FK. A CASE OF ACROMEGALY AND POLYGLANDULAR SYNDROME, WITH SPECIAL REFERENCE TO THE PINEAL GLAND. Arch Intern Med (Chic). 1913;XII(2):201–213. doi:10.1001/archinte.1913.00070020087008
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