A few months ago we reported in preliminary form1 the results of complete nitrogen partition studies on three carefully controlled normal cases and five pathological cases of pregnancy. We found that some instances of high ammonia could only be explained on the assumption that the bladder had been contaminated by the use of the catheter, and in one case of eclampsia we were able to demonstrate a marked fall in this constituent of the urine by the simple expedient of thoroughly washing the bladder with boric-acid solution twice in twenty-four hours. Because of the obvious importance of this source of error in judging the significance of such findings, we determined to follow up the practice of washing the bladder whenever a high amount of ammonia was encountered. In all properly conducted metabolism studies on the dog, the twenty-four-hour urines are obtained by catheter, by washing out the
MURLIN JR, BAILEY HC. FURTHER OBSERVATIONS ON THE PROTEIN METABOLISM OF NORMAL PREGNANCY. Arch Intern Med (Chic). 1913;XII(3):288–314. doi:10.1001/archinte.1913.00070030045006
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