Syphilis of the central nervous system is a manifestation of an infectious disease caused by a known parasite, against which we have at least two specific therapeutic agents. It is, therefore, amenable to treatment. The problems to be solved are : (1) How to recognize the condition before irreparable damage has been done to important structures; (2) the determination of the most efficient methods of application of our curative agents. The first can be solved only by careful clinical study and routine examination of the cerebrospinal fluid of all suspected patients. It is the purpose of this communication to present the results of an attempt to solve the second problem, viz., the determination of the best method of application of the curative agents.
The demonstration of the Treponema pallidum in general paralysis has definitely established the fact that in the so-called parasyphilitic nervous diseases there is active syphilis of the
HOMER F. SWIFT, ARTHUR W. M. ELLIS. THE TREATMENT OF SYPHILITIC AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM WITH ESPECIAL REFERENCE TO THE USE OF INTRASPINOUS INJECTIONS. Arch Intern Med (Chic). 1913;XII(3):331–345. doi:10.1001/archinte.1913.00070030088009