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November 1913


Author Affiliations


From the William Pepper Laboratory of Clinical Medicine. Under the J. Alison Scott Research Fund.

Arch Intern Med (Chic). 1913;XII(5):556-564. doi:10.1001/archinte.1913.00070050073007

In 1899 there appeared in the New York Medical Journal three admirable articles by Meltzer,1 in which he deals with the function of inhibition. He speaks of the entire life of the animal as being a delicately adjusted equilibrium between excitation and inhibition and cites instances in which the slightest deviation of the resultant in the nervous mechanism of an organ may lead to the most serious consequences.

A later article2 by the same author deals with the relation of inhibition to some forms of disease, and though it has paved the way for the more recent work brought forth by Eppinger and Hess3 in Vienna, only the latter work will be discussed here.

It is my purpose to present a brief summary of their work together with a clinical analysis of a number of cases which I have studied during the last year. At