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Article
March 1914

THE COAGULATION OF NORMAL HUMAN BLOOD: AN EXPERIMENTAL STUDY

Author Affiliations

BOSTON, MASS.

From the Pathological Laboratory of the Massachusetts General Hospital.

Arch Intern Med (Chic). 1914;XIII(3):398-425. doi:10.1001/archinte.1914.00070090051005
Abstract

INTRODUCTION  This paper represents a study of the essential processes involved in the coagulation of blood along lines recently worked out by Bordet and Delange.1This work has been carried out entirely with human blood. Nearly all the investigators in the field of coagulation of blood have worked with the blood of the lower animals. Bordet and Delange worked mostly with rabbits, somewhat with guinea-pigs and not at all with human blood. We have attempted to parallel the experiments of Bordet and Delange on rabbit's blood with experiments on human blood. We felt that such a study would not only confirm the important conclusions of Bordet and Delange but might perhaps permit a basis for deductions of clinical value. In addition we have subjected to critical study the procedures and experiments of Bordet and Delange and have attempted to carry still further the investigation of the problem of coagulation.

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