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Article
May 1914

EXPERIMENTAL STUDIES ON THE BLOOD-SERUM OF COWS IMMUNIZED AGAINST TUBERCULOSIS: "SENSITIZATION" OF LIVING TUBERCLE BACILLI

Author Affiliations

SARANAC LAKE, N. Y.

From Saranac Laboratory for the Study of Tuberculosis, Dr. E. L. Trudeau, Director.

Arch Intern Med (Chic). 1914;XIII(5):682-700. doi:10.1001/archinte.1914.00070110011002
Abstract

The experiments given in detail in this contribution relate to some calves that were immunized in 1902 and 1903 by intravenous inoculations of human tubercle bacilli. The results of various serum reactions, including complement deviation, agglutination and precipitation, were published in 1904.1 Bactericidal and bacteriolytic tests, which were briefly described at that time,2 were also performed with culture bacilli.

Nearly all the calves were killed at the conclusion of the first-mentioned experiments. Calf 5 was, however, retained for more than ten years, being repeatedly inoculated with cultures and extracts of tubercle bacilli. These were always of the human type, so that the actual test of immunity-inoculation of bovine bacilli was never made. Nevertheless, from the well-known protection acquired by calves under similar treatment, it is fair to assume that this animal was at least relatively immune. The further study of immune serums in general, and of

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