The presence of a proteolytic ferment in certain pathological exudates has long been known, and an examination of the literature discloses numerous investigations on the subject. Among these may be mentioned the work of E. Müller,1 who, by the use of serum plates, showed the marked proteolytic action of pus cells. In the course of his investigations he also studied various exudates and transudates and found that normal cerebrospinal fluid contained no proteolytic ferment. In the cerebrospinal fluid of purulent meningitis he demonstrated the presence of ferment which digested the serum plates; in tuberculous meningitis no digestion occurred. More recently Lenk and Pollak2 have found the presence of a proteolytic ferment in certain exudates and transudates. They used glycyl-tryptophan as an indicator for determining the presence or absence of such a ferment. Glycyl-tryptophan, as is well known, first came into prominence through the publications of
MAJOR RH, NOBEL E. THE GLYCYL-TRYPTOPHAN REACTION IN MENINGITIS. Arch Intern Med (Chic). 1914;XIV(3):383–387. doi:10.1001/archinte.1914.00070150096005
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