[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.204.227.250. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
November 1914

SPECIFIC HYPERLEUKOCYTOSIS: STUDIES IN TYPHOID IMMUNIZATION. IV

Author Affiliations

BERKELEY, CAL.

From the Hearst Laboratory of Pathology and Bacteriology, University of California.

Arch Intern Med (Chic). 1914;XIV(5):662-670. doi:10.1001/archinte.1914.00070170055004
Abstract

We have already briefly described the specific and extreme grade of hyperleukocytosis that follows the intravenous injection of living typhoid bacilli in rabbits that have been immunized against this microorganism.1 In the present communication we wish to consider more fully the detail and mechanism of this phenomenon and its analog in other types of protein immunization.

The importance of the polymorphonuclear leukocytes in both natural and acquired immunity against bacteria has been well and advisedly emphasized by Metchnikoff and his pupils.2 The observations on the importance of leukocytes in immunity have dealt, however, with the qualitative rather than the quantitative response of these cells to the infecting agent. Our work, we believe, points out the existence and importance of a quantitative leukocyte response in cases in which recovery from an acute infection occurs abruptly.

The injection of apparently any foreign protein substance in normal animals

×