We have already briefly described the specific and extreme grade of hyperleukocytosis that follows the intravenous injection of living typhoid bacilli in rabbits that have been immunized against this microorganism.1 In the present communication we wish to consider more fully the detail and mechanism of this phenomenon and its analog in other types of protein immunization.
The importance of the polymorphonuclear leukocytes in both natural and acquired immunity against bacteria has been well and advisedly emphasized by Metchnikoff and his pupils.2 The observations on the importance of leukocytes in immunity have dealt, however, with the qualitative rather than the quantitative response of these cells to the infecting agent. Our work, we believe, points out the existence and importance of a quantitative leukocyte response in cases in which recovery from an acute infection occurs abruptly.
The injection of apparently any foreign protein substance in normal animals
GAY FP, CLAYPOLE EJ. SPECIFIC HYPERLEUKOCYTOSIS: STUDIES IN TYPHOID IMMUNIZATION. IV. Arch Intern Med (Chic). 1914;XIV(5):662–670. doi:10.1001/archinte.1914.00070170055004
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