The increasing use of hexamethylenamin for pathological conditions has led to more systematic studies of its chemical and bactericidal properties, and, as a result, recent literature abounds with papers on the subject. Following the discovery by Nicolaier,1 in 1894, that hexamethylenamin was broken down into formaldehyd in the urine, this drug was used extensively in infections of the genito-urinary tract. Up to 1902 the literature contained many papers on its use, a good review of which may be found in the paper by Lubowski.2 For a few years after 1902 very little new work was done on hexamethylenamin as an antiseptic agent until 1908, when Crowe3 demonstrated its presence in body-fluids other than the urine. Since that time there has been a revival of interest in this drug and its uses, and as a result it has become more or less a panacea for many ills
LEVY LH, STRAUSS A. A CLINICAL AND BACTERIOLOGICAL STUDY OF HEXAMETHYLENAMIN AS A URINARY ANTISEPTIC. Arch Intern Med (Chic). 1914;XIV(5):730–742. doi:10.1001/archinte.1914.00070170123008
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