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Article
December 1914

A CLINICAL STUDY OF TWO HEPATIC FUNCTIONAL TESTS: (GALACTOSE AND PHENOLTETRACHLORPHTHALEIN)

Author Affiliations

BOSTON

From the Medical Service of the Peter Bent Brigham Hospital, Boston.

Arch Intern Med (Chic). 1914;XIV(6):804-826. doi:10.1001/archinte.1914.00070180037004
Abstract

The object of this paper is to add further clinical observations to those already assembled on the subject of hepatic function. A voluminous literature has been assembled already on the subject both from an experimental and clinical standpoint. A very excellent general review of this is set forth in Holweg's1 publication later reviewed and amplified by Riess and Jehn.2 The more recent work has been presented by Rowntree, Hurwitz and Bloomfield.3 In this study we have limited ourselves to the use of two tests, namely, the galactose test and the phenoltetrachlorphthalein test. These seemed to offer the greatest possibilities from a clinical point of view.

I. GALACTOSE TEST  The structural formula of d-galactose is CH2OH (CHOH)4 COH. Its stereo-isomere is dextrose. It can be formed by hydrolysis from lactose. It rotates polarized light to the right. It ferments with greater difficulty than

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