Various attempts have been made to simplify the technic of the Abderhalden dialysis test, but without success. Some of the investigators have applied the technic originally described by him with the use of the urine instead of the blood serum. The results have been variable.
The theoretical basis for the use of the urine has been on the supposition that the enzymes which dialyze through a parchment thimble pass through the kidney and are found in the urine (Berman,1 Malone2).
L. M. Warfield3 had reported seventeen analyses (Abderhalden method) on urines of pregnant women in which he had obtained positive reactions in all. Fischer4 pointed out later that Warfield3 had omitted the urine of males and nonpregnant females as controls. Fischer4 found that in his laboratory all urines with few exceptions gave a positive ninhydrin reaction. These findings coincide with my
BERKOWITZ S. THE MALONE-KIUTSI REACTIONS IN PREGNANCY AND CANCER. Arch Intern Med (Chic). 1917;XIX(3):397–403. doi:10.1001/archinte.1917.00080220064006
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