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Article
April 1917

THE EFFECT OF MUSCULAR WORK, DIET AND HEMOLYSIS ON THE SERUM PROTEINS: TOGETHER WITH COMMENT ON THE TECHNIC AND CLINICAL USEFULNESS OF ROBERTSON'S MICROREFRACTOMETRIC METHOD

Author Affiliations

OAKLAND, CALIF.

From the Medical Service and Chemical Laboratory of the Massachusetts General Hospital, Boston.

Arch Intern Med (Chic). 1917;XIX(4):499-506. doi:10.1001/archinte.1917.00080230002001
Abstract

MUSCULAR WORK  Böhme1 has shown that muscular work, even of the simplest sort, increases the serum concentration. Schwenker2 found this concentration returned to a constant normal level after the patient had reclined quietly for twenty minutes. His explanation of the increase was that during work, blood pressure rises, which forces protein-poor fluids out of the blood vessels into the surrounding tissues. Reiss,3 on the other hand, thought that during activity muscles take up considerable water, giving it up during rest.Our investigations on this effect of work on serum proteins in normal men show a very decided increase in the total proteins, which increase occurs more in the albumin than in the globulin fraction. The nonproteins increase very slightly. The work done was on a bicycle ergometer to a point where the subjects were near exhaustion, except in Case 3, in which

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