In a study of this question by Dr. D. J. Davis,1 he arrives at the following conclusion :
Sodium salicylate does not exert a favorable effect on infections in rabbits caused by various types of streptococci. It does not prevent localization of the organism in joints, nor does it prevent the appearance of endocarditis. It would seem to have, therefore, no prophylactic value, nor does it alter the course of the infection after it has once become established.
In these experiments sodium salicylate was used in a dose of 0.3 gm. administered subcutaneously once daily. In view of the great importance of the question, and the fact that the subcutaneous administration of a single daily dose by no means reproduces the usual therapeutic administration of this remedy in human beings, and as only large doses produce marked effect in human rheumatism, and the daily dose of 0.3 gm. does
FANTUS B, SIMMONDS WE, MOORE JJ. THE EFFECT OF SALICYLATES ON EXPERIMENTAL ARTHRITIS IN RABBITS. Arch Intern Med (Chic). 1917;XIX(4):529–537. doi:10.1001/archinte.1917.00080230032004
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