Prior to the experiments of Blum1 in 1901, when he demonstrated that injections of a watery extract of the adrenal glands constantly give rise to glycosuria in dogs, very little attention had been given to the action of the suprarenal secretion on metabolism. Claude Bernard's2 conception of an internal secretion enunciated in 1855, and the publication, in the same year, of Thomas Addison's book containing his observations on the association of a definite clinical syndrome with pathologic changes in the adrenal glands, prepared the way for BrownSéquard's3 well known experiments. His conclusions, though in part erroneous, were epoch-making. Because of the stimulus it supplied to investigations in the new field of internal secretion, the value of this work was tremendous. But so far as the adrenals were concerned, these early researches had been confined chiefly to studies of their effect on blood pressure, local changes
MACKENZIE GM. THE SUPRARENAL SYSTEM AND CARBOHYDRATE METABOLISM. Arch Intern Med (Chic). 1917;XIX(4):593–610. doi:10.1001/archinte.1917.00080230096009
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