A study of the syndrome known as nephritis should throw a great deal of light on many problems of normal and pathologic physiology. The disease is accompanied by profound changes of long duration, and the organism is obliged to adapt itself to conditions which are very different from those found in health. For this reason the investigator can obtain in the study of nephritis much information as to the manner in which the total metabolism is influenced by certain factors. Chief among these are nitrogen retention, edema, high blood pressure, acidosis and the conditions which cause uremia. Unfortunately, we know little about these factors, and suspect the presence of many more about which we know nothing. At this stage, all that one can do is to present his findings as completely as possible in the hope that they will be of service to those who can some day solve the
AUB JC, Du BOIS EF. CLINICAL CALORIMETRY: TWENTY-SECOND PAPER THE RESPIRATORY METABOLISM IN NEPHRITIS. Arch Intern Med (Chic). 1917;XIX(5_II):865–889. doi:10.1001/archinte.1917.00080250044004
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