Cases of syphilis with positive findings in the spinal fluid treated during a period of three years following the opening of the Peter Bent Brigham Hospital may be divided into three groups. The patients of one group were treated with salvarsan, mercury and potassium iodid for a sufficiently long time to determine whether or not clinical and laboratory improvement would follow. If there was definite improvement, no change was made in the therapy. If improvement did not follow after a reasonable length of time, they were shifted into a second group the members of which received in addition to the above, salvarsanized serum intraspinally. In a third group were placed those patients having negative blood Wassermann reactions, and to them salvarsanized serum alone was given. Seventy-five patients were treated under this plan, and to them 450 intraspinal injections of salvarsanized serum were given in addition to the
HALLER DA. THE TREATMENT OF SYPHILIS OF THE CENTRAL NERVOUS SYSTEM: A COMPARISON OF MERCURIALIZED SERUM AND SALVARSANIZED SERUM. Arch Intern Med (Chic). 1917;XIX(6):997–1015. doi:10.1001/archinte.1917.00080260040004
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