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Article
June 1917

THE SALICYLATES: VI. RENAL, FUNCTIONAL AND MORPHOLOGIC CHANGES IN ANIMALS FOLLOWING THE ADMINISTRATION OF SALICYLATE

Arch Intern Med (Chic). 1917;XIX(6):1016-1028. doi:10.1001/archinte.1917.00080260059005
Abstract

It was previously shown1 that individuals receiving full therapeutic doses of salicylate invariably have albumin, leukocytes and casts or cast-like bodies in the urine. This albuminuria is produced in both febrile and afebrile individuals, and is of renal origin. The functional tests (phenolsulphonephthalein excretion in urine and nonprotein nitrogen of the blood) which were applied at the time, gave inconstant results, and the changes in some cases were so small that it was impossible to conclude definitely whether any serious impairment in the functional efficiency of the kidney existed. It is possible that repeated administration of salicylate might cause more definite and marked changes in the kidney, both functionally and morphologically. Moreover, in certain individuals, the albuminuria and other changes are so severe that the presence of a definite nephritis is suggestive. Von Ackeren2 gave sodium salicylate and salicylic acid per os to five rabbits, and two

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