THE VALIDITY OF EXPERIMENTAL RESULTS IN THE INTERPRETATION OF CARDIAC AFFECTIONSThe experimental investigator who, within the span of at most a few hours, seeks to reproduce in animals the cardiac affections which Nature pleases to produce in man in a slow and gradual fashion, runs the risk of bringing about conditions which may not be comparable to those actually existing in diseased individuals. Thus, the sudden tearing of a valve may produce a reaction in experimental animals that is more serious than a similar insufficiency, the gradual development of which is accompanied by compensatory phenomena. It becomes a part of the experimental problem, therefore, not only to elucidate the dynamic effects of a certain pathological change, but also to determine, as completely as possible, the influence that secondary accompaniments to such a condition have on the primary affection.Moreover, the hearts of animals on which experimental work
WIGGERS CJ. STUDIES ON THE PATHOLOGICAL PHYSIOLOGY OF THE HEART: I. THE INTRA-AURICULAR, INTRAVENTRICULAR AND AORTIC PRESSURE CURVES IN AURICULAR FIBRILLATIONS. Arch Intern Med (Chic). 1915;XV(1):77–91. doi:10.1001/archinte.1915.00070190080005
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