Since the work of Nicolaier and Dohrn1 showing an increased elimination of uric acid, due to the action of 2-phenylquinolin-4-carboxylic acid (atophan), a great deal of work has been done by many investigators with this substance. All get results showing an increased elimination, but all are not in accord in explaining the mechanism by which this increased elimination is obtained. Weintraud,2 as well as Frank and Bauch,3 have concluded from results of experiments in which uric acid was injected and sodium nucleinate was fed, that the atophan acts by increasing the efficiency of the kidney for uric acid elimination. Deutsch,4 Folin and Lyman5 and Zuelzer6 have reached the same conclusion by showing a decrease in the uric acid content of the blood, after the administration of atophan. Retzlaff7 and Brugsch,8 as well as Gudzent, Klemperer and Dohrn (cited
SMITH CA, HAWK PB. ACTION OF ATOPHAN AND NOVATOPHAN IN GOUT AND IRITIS. Arch Intern Med (Chic). 1915;XV(2):181–187. doi:10.1001/archinte.1915.00070200003001
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