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Article
February 1915

METABOLISM STUDY OF A CASE OF CONGENITAL HEMOLYTIC JAUNDICE WITH SPLENOMEGALY

Author Affiliations

PITTSBURGH

From the Laboratory of Dr. James P. McKelvy, Pittsburgh.

Arch Intern Med (Chic). 1915;XV(2):227-238. doi:10.1001/archinte.1915.00070200049004
Abstract

I. INTRODUCTION  The interesting syndrome of chronic acholuric, pleiochromic jaundice without the usual syndrome of biliary intoxication associated with anemia and splenomegaly was first noted clinically by Murchison1 in 1883. Minkowski2 in 1900, however, reported a very complete study of a group of cases occurring in one family. Excellent reviews of the subject, together with the literature, have been presented by Tileston and Griffin3 and by Thayer and Morris,4 so we shall in this paper consider only those details which have relation to the experimental work to be described.Besides the usual hereditary form of this disease, there is a familial type and a congenital type, in which the disease dates from birth and appears in only one of the family. It may be noted from the history that the case described in this paper belongs to this type. Another type is the so-called

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