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February 1915

OBSERVATIONS ON RENAL FUNCTION IN ACUTE EXPERIMENTAL UNILATERAL NEPHRITIS

Arch Intern Med (Chic). 1915;XV(2):303-328. doi:10.1001/archinte.1915.00070200125009
Abstract

The study of renal function during the past few years has occupied considerable attention in both clinical and experimental laboratories. A number of different tests have been advocated by different observers, but so far no attempt has been made, in experimental surgery, to compare a variety of these tests on the same animal at the same time. This paper describes experiments which were made to establish an acute unilateral nephritis in dogs, and records the studies on renal function in this condition to determine which of the tests used most commonly in the surgical clinic are of greatest practical value in the diagnosis of one-sided lesions of varying severity.

An experimental one-sided nephritis has already been produced. In 1883, Ribbert1 excised the medulla of one kidney in rabbits in his experiments on renal physiology. Boyd2 and Oppenheimer3 confirmed this method of producing a unilateral lesion by using

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