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February 1915


Author Affiliations


From the Medical Service and the Chemical Laboratory of the Massachusetts General Hospital.

Arch Intern Med (Chic). 1915;XV(2):329-338. doi:10.1001/archinte.1915.00070200151010

Recently two cases with histories of periodic attacks of generalized edema without the usual evidence of kidney disease have been under observation in the Massachusetts General Hospital. These seem, together with certain chemical investigations on them, to be of sufficient interest to be reported.

Case 1. 

—History.  Mrs. D., aged 33, in excellent circumstances, at an early age was operated on for acute appendicitis. Since this operation a previous troublesome constipation has been more marked. In 1909, at the end of her last pregnancy, she was seriously ill with the kidney of pregnancy. During this time there appeared in the urine large amounts of albumin and casts which gradually disappeared after the birth of the child. For the past three or four years she has been engaged actively in social and philanthropic interests.In June, 1913, the patient came to Dr. Edsall for the first time, complaining of

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