In the following pages arguments in favor of the view that hemoglobin pigment is produced and decomposed in the liver are presented.
This view was suggested by work which has already been published from this laboratory, and to some extent the evidence in favor of it is drawn from that source. New work has been started on the basis of this hypothesis along several lines, but there are so many questions raised, which circumstances prevent us from attempting to answer, that it seemed better to present what evidence we have at present.
It is claimed that those data which we already possess are harmonized and rendered intelligible by the adoption of this view, and that there is sufficient evidence to justify its acceptance as a working hypothesis.
As it was in the hope that applications to clinical medicine might be found that the subject was approached, special stress
ADDIS T. A WORKING HYPOTHESIS OF HEMOGLOBIN PIGMENT METABOLISM. Arch Intern Med (Chic). 1915;XV(3):413–437. doi:10.1001/archinte.1915.00070210074005
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