The question of the etiological basis of that type of lymph-node hypertrophy referred to as Hodgkin's disease, has for many years been of much interest. There have been two principal ideas in regard to this type of lymph-node hyperplasia ; one that it is a neoplasm of the lymphoblastic elements of the lymph-nodes, the other that it is an inflammatory reaction accompanying or following an infection with some micro-organism which attacks especially the lymph-nodes. The advocates of each of these theories have referred to the histological findings in the lymph-nodes as evidence in support of one or the other of the two theories referred to above. Among others, Gibbons,1 has expressed the opinion that the enlarged nodes belong in the group of malignant neoplasms. Opposed to this view are McCallum, Longcope, Reed and others who have claimed that the histological findings in the lymph-nodes are those associated with a
RHEA LJ, FALCONER EH. A REPORT OF THE BACTERIOLOGICAL EXAMINATION OF ENLARGED LYMPH-NODES REMOVED FROM A PATIENT WITH HODGKIN'S DISEASE. Arch Intern Med (Chic). 1915;XV(3):438–443. doi:10.1001/archinte.1915.00070210099006
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