It is a well substantiated clinical observation that injuries involving the base of the cranium frequently are followed by polyuria which may or may not be accompanied by glycosuria. It is also just as well substantiated that growths which involve the base of the brain, especially the region of the third ventricle, may likewise give rise to polyuria which may be accompanied by hyperglycemia sufficient to produce glycosuria. These conditions when arising from fractures of the base of the skull generally are of short duration, but when they result from growths in the region above mentioned, may be more or less persistent. The first experimental evidence that injuries to the base of the brain (in the region of the fourth ventricle) gave rise (under certain conditions of the animal operated on) to polyuria accompanied by hyperglycemia and glycosuria was furnished by the classic experiment of Bernard known as the
MATTHEWS SA. EXPERIMENTAL DIABETES INSIPIDUS IN DOGS. Arch Intern Med (Chic). 1915;XV(3):451–457. doi:10.1001/archinte.1915.00070210112008
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