In a publication by one1 of us, it was shown that in emphysematous patients (the minute volume and rate of respiration remaining the same) the concentration of carbon dioxid in the alveolar air increased when the degree of emphysema increased. It was also shown that this increased concentration of carbon dioxid in alveolar air was not caused by impairment of the function of external respiration, but was due to impairment of the ventilatory function of the lung. It was at first suspected that the dead space was increased in emphysema but when we collected the entire minute volume of air in a large rubber bag and took samples of alveolar air during the collection of the minute volume of air, we found that the dead space in patients who had severe emphysema was no larger than in normal persons. A large rubber bag 20 inches square was used
HOOVER CF. THE DEAD SPACE IN MODERATE AND LARGE RESPIRATORY VENTILATION. Arch Intern Med (Chic). 1915;XV(4):501–513. doi:10.1001/archinte.1915.00070220003001
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