The following experiments were made in order to determine the effect of salicylates in animals inoculated with various types of streptococci. These cocci were isolated from various sources, and their causal relation to certain clinical conditions, especially of the rheumatic types, is pointed out in its appropriate place with the several series of experiments reported below. The experiments with the different organisms were all carried on in the same way. The animals used were rabbits. They were given, in some cases on the previous day, in other cases from one to two hours previous to inoculation, 5 grains of a synthetic preparation1 of sodium salicylate subcutaneously or intramuscularly. They were then inoculated intravenously with suitable doses of living suspensions of twenty-four-hour cultures of the streptococci. On each subsequent day from 3 to 5 grains of salicylate were given to the animals, usually subcutaneously, for a period of
DAVIS DJ. THE EFFECT OF SODIUM SALICYLATE ON VARIOUS TYPES OF EXPERIMENTAL ARTHRITIS. Arch Intern Med (Chic). 1915;XV(4):555–557. doi:10.1001/archinte.1915.00070220057006
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