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May 1915


Arch Intern Med (Chic). 1915;XV(5_1):754-757. doi:10.1001/archinte.1915.00070230111008

The instances of renal disease in which exclusively one portion of the anatomical structure of the kidney has received injury are so excessively infrequent that they at once excite interest as means of testing our conceptions of physiological functions of this organ and the mode of origin of some signs of disease. These conditions are, patently, those of successful experimentation. That the occasional cases of toxic nephritis in man have not been more fruitful in yielding information applicable to broader studies is due chiefly to the great rapidity and severity of the symptoms, culminating after a few days in death. Instances of fatal poisoning with mercuric chlorid are common, and there is a well recognized type of lesion found in the kidney in these cases ; but as the period of life after ingestion of the poison is relatively brief, the signs and symptoms of renal injury are obscured and

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