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June 1915


Author Affiliations


From the Pathological Laboratory, Mt. Sinai Hospital.

Arch Intern Med (Chic). 1915;XV(6):1014-1039. doi:10.1001/archinte.1915.00070250075005

I. INTRODUCTION  In 1907 my attention was first called by Dr. E. Libman to an observation which he had made on a patient who had been bitten by a rat, and who, two weeks later, had developed an irregular and intermittent fever, accompanied by a diffuse erythema, and terminating in recovery without sequelae. Though no distinct scientific data were taken at the time, the unusual character of the symptoms attracted his attention. Soon afterward, two other somewhat similar occurrences were remarked by medical associates, but no opportunity was afforded for personal observation of these cases.The appearance of an article by Horder1 in 1910 describing three cases of irregular fever following the bite of a rat, and the almost simultaneous occurrence in the wards of Mt. Sinai Hospital of an undoubted instance of similar nature, afforded the opportunity of making a complete study and examination of all the

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