It has long been recognized that in certain cases of obstructive jaundice there is a tendency to hemorrhage due to the delayed coagulation of the blood. Morawitz and Bierich1 studied the causes of bleeding in cholemia and came to the conclusion that the altered coagulation time in these cases could be traced to delayed formation of fibrin ferment. They attributed this delay to a diminution or absence of thrombokinase. They believed that the altered coagulation time was not due to the presence of cholates or biliary acids in the blood and was independent of the duration or intensity of the jaundice. Kunika2 investigated the clinical value of the determination of the coagulation time in cases of icterus and concluded that the delay was due to a decrease in the liver function. King and Stewart,3 in the course of an investigation of the cause of
LEE RI, VINCENT B. THE RELATION OF CALCIUM TO THE DELAYED COAGULATION OF BLOOD IN OBSTRUCTIVE JAUNDICE. Arch Intern Med (Chic). 1915;XVI(1):59–65. doi:10.1001/archinte.1915.00080010064005
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