I. PREVIOUS EXPERIMENTAL WORK
Since Corrigan,1 in 1832, first described and gave a logical explanation of the collapsing pulse often associated with aortic incompetency, clinicians and physiologists alike have given their interpretations of the circulatory changes inaugurated by a leakage of the aortic valves. In this, as in other provinces of medicine, it is important to differentiate between demonstrated facts and convenient assumptions to explain clinical observations. It is but natural, therefore, that the subject should have been the cause of considerable experimental investigation.In 1878, Rosenbach2 punctured the aortic valves in rabbits by a glass rod introduced through the right carotid. This caused no variation of mean arterial pressure. Cohnheim3 confirmed this result but Goddard4 obtained a fall of mean arterial pressure. De Jager,5 in 1883, obtained no variation after puncturing the valve segments in dogs, but in rabbits he
WIGGERS CJ. STUDIES ON THE PATHOLOGICAL PHYSIOLOGY OF THE HEART: II. THE DYNAMICS OF AORTIC INSUFFICIENCY. Arch Intern Med (Chic). 1915;XVI(1):132–148. doi:10.1001/archinte.1915.00080010137010
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