The uncertain nature of the hemolytic reaction characteristic of paroxysmal hemoglobinuria presents a problem of continued interest. The majority of investigators are agreed that the theory originally put forward by Donath and Landsteiner1 explains in a general way the mechanism by which a paroxysm is brought about. But concerning the number and character of the different factors involved and the physical conditions under which they act, there are almost as many opinions as there are writers.
The first part of the paper is a study of this reaction. The second part deals with the quantity of blood destroyed during an experimental exposure to cold and the rapidity of the consequent excretion of hemoglobin by the kidneys.
As the literature contains many clinical descriptions of this condition, only a short history will be given and enough of the physical findings to establish the diagnosis and corroborate
DENNIE CC, ROBERTSON OH. STUDY OF A CASE OF PAROXYSMAL HEMOGLOBINURIASERUM REACTIONS: UROBILIN AND HEMOGLOBIN EXCRETION. Arch Intern Med (Chic). 1915;XVI(2):205–212. doi:10.1001/archinte.1915.00080020059004
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