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September 1915


Author Affiliations


From the Department of Medicine of Harvard University and the Medical Clinic of the Peter Bent Brigham Hospital.

Arch Intern Med (Chic). 1915;XVI(3):503-508. doi:10.1001/archinte.1915.00080030172013

Cystinuria is a rare but very interesting disease. Its chief interest is from the point of view of body metabolism and the various careful studies of this disease have added much to our knowledge of protein katabolism. The treatment of the disease has received but little consideration.

Cystinuria has a definite symptom-complex and may be readily diagnosed. The symptoms are those of renal stone, and differ but little from those of other types of renal-stone disease. Certain features, however, are somewhat characteristic.

  1. The stones are usually very small. They are sharp edged, rough, with a color and texture very similar to that of a small piece of maple sugar.

  2. The stones tend to occur in the urine in showers, usually after a period of high protein ingestion.

  3. The amount of blood in the urine is often out of proportion to the symptoms and to the

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