It was noted at autopsy in a study of animals dying after the removal of both adrenals that the pancreas always presents a characteristic appearance. In color the gland is deep pink and contrasts quite strikingly with the faint white color of the normal pancreas. Because of their marked injection, it is possible to see all the vessels by transmitted light; even those leading to the small lobules stand out prominently. Histologically the islands appear prominent and the capillaries are engorged with blood. This appearance is only slightly simulated by that of the fatigue gland at the end of a long period of digestion. Since these changes in the pancreas were so marked and constant, we deemed them worthy of a separate investigation. This seemed especially desirable as accurate data in regard to the polyglandular theory are very scant. We found only one reference describing a seemingly
MANN FC, DRIPS D. THE RELATION OF THE ADRENALS TO THE PANCREAS. Arch Intern Med (Chic). 1915;XVI(4):681–692. doi:10.1001/archinte.1915.00080040177012
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