Few have studied the prothrombin and antithrombin factors of coagulation of the blood in human cases. Howell1 devised methods to study these factors and has reported a deficiency of prothrombin in hemophilia with relative excess of antithrombin, a diminution of antithrombin in cases of spontaneous thrombosis and no abnormality in the cases of purpura he studied.
Whipple2 reported increased amounts of antithrombin and a prothrombin deficiency in hemorrhagic cases, but his results are to be criticized in that he did not take into consideration normal variations, and that dog blood was used to control human. Austin and Pepper3 have made studies on the coagulation of oxalated plasma. In one case of purpura they found delayed coagulation on recalcification in the presence of thromboplastic solutions and attributed it to increased antithrombin. Since our work was begun, Hess,4 using Howell's methods, has published the results of a
MINOT GR, DENNY GP. PROTHROMBIN AND ANTITHROMBIN FACTORS IN THE COAGULATION OF BLOOD. Arch Intern Med (Chic). 1916;XVII(1):101–139. doi:10.1001/archinte.1916.00080070119008
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