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Article
March 1916

SOME ATTEMPTS TO PRODUCE EXOPHTHALMOS EXPERIMENTALLY

Author Affiliations

STOCKHOLM, SWEDEN

From the Department of Pathology, Columbia University, College of Physicians and Surgeons, New York City.

Arch Intern Med (Chic). 1916;XVII(3):382-395. doi:10.1001/archinte.1916.00080090041004
Abstract

In a paper1 published in 1914 I endeavored, on the basis of a number of clinical and experimental observations, to make a contribution to our knowledge of the pathogenesis of the eye symptoms in exophthalmic goiter. I dwelt in that connection particularly on Landström's explanation of their origin, and, making reference to our present anatomic and clinical information, expressed my doubts as to the possibility of maintaining Landström's theory. The chief points on which I based my remarks were the following:

1. The "Landström muscle," or rather the musculus capsulopalpebralis (Hesser2), is so weak and so asymmetrically placed as to be hardly capable of producing alone the pronounced eye symptoms which are not infrequently observed in exophthalmic goiter. Above all, it is difficult to understand how a contraction of that muscle should produce a pronounced shifting forward of its posterior origin (of the region about the

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