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April 1916


Arch Intern Med (Chic). 1916;XVII(4):465-475. doi:10.1001/archinte.1916.00080100009002

We recently made urine and blood examinations in a typical case of progressive muscular dystrophy which was being studied clinically by Drs. Goldthwait and Spear of Boston. The clinical findings are to be made the subject of a separate report, but the chemical findings seem well worth recording, even though they represent the data from but one case, since, if confirmed in other cases, they constitute a distinct contribution to our knowledge of carbohydrate metabolism. They are, therefore, published in the hope that similar examinations will be made by any other investigators who may observe a case of this uncommon disease.

THE OBSERVATIONS  The patient was a man 33 years of age who showed no abnormalities except progressive muscular weakness. He was put on a constant diet; the urine was saved and examined quantitatively for calcium, magnesium, nitrogen, creatinin, creatin, uric acid, and ammonia ; and the blood for

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