In 1914 Hedinger and Schlayer1 described a dietary test for renal function which consisted in estimating the amount of urine, its specific gravity, and its content in sodium chlorid and nitrogen, both the total amount and percentage concentration in two hour specimens collected throughout the day and in a single night specimen Their patients were placed on a special diet so arranged that different meals given throughout the day should have varying amounts of fluids, sodium chlorid, protein and purin bases. Slight modifications of these diets will be found in the papers published by Mosenthal2 from the Johns Hopkins Hospital Clinic, and O'Hare3 from the Peter Bent Brigham Hospital Clinic.
A normal person under the conditions of such a diet shows variations in all of the factors determined in the test in relation to the meals, so that when the results
CHRISTIAN HA. RENAL FUNCTION IN PERNICIOUS ANEMIA: AS DETERMINED BY DIETARY RENAL TESTS. Arch Intern Med (Chic). 1916;XVIII(4):429–444. doi:10.1001/archinte.1916.00080170002001
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