Since the classical work of von Pirquet and Schick on serum disease, it has been repeatedly observed that with the edema which appears in the course of this illness, albumin and occasionally casts may occur in the urine, and a few observers have noted suppression of urine with subsequent albuminuria and cylindruria during severe immediate or accelerated reactions following a second dose of serum. Though these symptoms are said to be transient, no accurate studies have so far been made to determine whether actual changes take place at this time in the functional activity of the kidneys, and since it has been shown by one of us1 that repeated injections of foreign protein in sensitized animals may lead to damage of the kidney, as well as to the other organs, it seemed important to determine whether the edema, which is often general in serum disease, is associated with
RACKEMANN FM, LONGCOPE WT, PETERS JP. THE EXCRETION OF CHLORIDS AND WATER AND THE RENAL FUNCTION IN SERUM DISEASE. Arch Intern Med (Chic). 1916;XVIII(4):496–504. doi:10.1001/archinte.1916.00080170069005
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