The term acidosis as it is used in medicine at the present time does not designate a definite clinical entity, but is applied to a variety of conditions in which, as Sellards1 expresses it, there is a general impoverishment of the body in bases or substances which readily give rise to bases. This impoverishment in bases may be due to faulty absorption of bases, to an unusual loss of them from the body, or to their neutralization by abnormal amounts of acids. Increase in the amounts of acids in the body may be due to the production of abnormal acids, an overproduction of the usual body acids, or, as Howland and Marriott2 have recently suggested, to an accumulation of normal acids due to failure in excretion.
It is difficult, if not impossible, at the present time to estimate what are the normal
FROTHINGHAM C. ACIDOSIS IN ACUTE AND CHRONIC DISEASE. Arch Intern Med (Chic). 1916;XVIII(6):717–732. doi:10.1001/archinte.1916.00080190002001
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